Dr.-Ing. Barbara Wirthl

Contact

• Room 1231
• Email: barbara.wirthl(at)tum.de
• Phone: +49 (0) 89 289 15235

Research interests

• Computational Transport Oncophysics
• Nanomedicine
• Immunotherapy
• Sensitivity analysis, uncertainty quantification and inverse analysis
• Porous Media

Teaching

• Nichtlineare Kontinuumsmechanik (WiSe 24/25)
• Einführung in aktuelle Forschungsthemen der Numerischen Mechanik (WiSe 24/25)
• A Practical Course in Numerical Methods for Engineers (WiSe 18/19, 19/20, 20/21, 21/22, 22/23)
• Biomechanik - Grundlagen und Modellbildung (SoSe 19, 20, 21, 22)

Publications

PhD Thesis

Wirthl B., Physics-based and probabilistic computational approaches for nanomedicine in oncology, 2024.

Publications in peer-reviewed journals

Wirthl B., Wirthl V., Wall W. A. (2024), Efficient computational model of the in-flow capturing of magnetic nanoparticles by a cylindrical magnet for cancer nanomedicine, Physical Review E, 109(6), 065309, doi:10.1103/PhysRevE.109.065309

Wirthl B., Janko C., Lyer S., Schrefler B. A., Alexiou C., Wall W. A. (2024), An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow, Biomedical Microdevices, 26(1). doi:10.1007/s10544-023-00685-9

Wirthl B.*, Hervas-Raluy S.*, Enrique Guerrero P., Robalo Rei G., Nitzler J., Coronado E., Font de Mora J., Schrefler B. A., Gomez-Benito M. J., Garcia-Aznar J. M., Wall W.A. (2023), Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment, Computers in Biology and Medicine, 106895. doi:10.1016/j.compbiomed.2023.106895 (*co-first authorship)

Wirthl B., Brandstaeter S., Nitzler J. Schrefler B.A., Wall W.A. (2022), Global sensitivity analysis based on Gaussian-process metamodelling for complex biomechanical problems, Int J Numer Meth Biomed Engng., 39(3):e3675. doi:10.1002/cnm.3675

Wirthl B.*, Kremheller J.*, Schrefler B.A., Wall W. A. (2020), Extension of a multiphase tumour growth model to study nanoparticle delivery to solid tumours, PLOS ONE, 15(2):e0228443, doi:10.1371/journal.pone.0228443 (*co-first authorship)

Fletcher, T.L., Wirthl, B., Kolias, A.G. et al. (2016), Modelling of Brain Deformation After Decompressive Craniectomy. Ann Biomed Eng 44, 3495–3509, doi:10.1007/s10439-016-1666-7

Supervised Student Projects 

• Computational modelling of angiogenesis governed by the tumour microenvironment, Master's Thesis
• Computational modelling of interactions between interstitial fluid flow and angiogenesis in solid tumours, Term Paper
• Computational Modelling of in Vitro Tumour Growth: From Imaging Data to Bayesian Inverse Analysis, Term Paper
• A Bayesian Inference Approach for Optimal Tumour Treatment Using Gaussian Processes, Term Paper (co-supervised with Jonas Nitzler)
• A study of pharmacokinetics and pharmacodynamics in a multiphase tumour growth model, MSE research internships (co-supervised with Johannes Kremheller)
• 3D Visualisation of tumour growth, Visualization Techniques in Computational Mechanics
• Output Monitoring Routines for Parameter Studies in a Finite Element Tumour Growth Model, Bachelor's Thesis (co-supervised with Johannes Kremheller)

Education

• 2018-2023 PhD, Technische Universität München, Germany
• 2018 Master of Science (M.Sc.), Mechanical Engineering, Technische Universität München, Germany